In this study we hypothesized that to maintain a high efficient flow of glycolysis, hepatocarcinoma employs an altered pathway to escape gluconeogenesis. Our data show that malignant hepatocytes ...

Phosphofructokinase is required in the glycolysis pathway and bisphophatase in the gluconeogenesis pathway. The phosphatase arm of PFKFBP transforms F2,6P into F6P. PKA phosphorylates the kinase ...

Another pathway of inhibiting gluconeogenesis is by phosphorylation of class IIa histone acetylates by AMPK. AMPK inhibits protein synthesis by inhibition of cap-dependent translation and indirect ...

In patients, the glucose synthesis pathway in the liver (gluconeogenesis) is hyperactivated, a process that can be controlled by drugs such as metformin. "Recently, new factors involved in the ...

Gluconeogenesis using glycerol as a substrate in bloodstream-form Trypanosoma brucei. PLOS Pathogens , 2018; 14 (12): e1007475 DOI: 10.1371/journal.ppat.1007475 Cite This Page : ...

This study was published online in PNAS on May 30. Elevated gluconeogenesis and excessive glucose production in the liver contribute to hyperglycemia and type 2 diabetes. Prolyl hydroxylase (PHD ...