Core promoter mutations were seen in five of the eight ... none of the 15 patients (two died of HCC) at the last follow-up showed HBeAg seroconversion and response to therapy.

In both studies, researchers identified mutations that created new binding sites in the TERT promoter for particular transcription factors and resulted in increased transcriptional activity at the ...

Up to 60% of HCM cases ... individuals are carrying a monogenic mutation in DiNAQOR genes of interest,” he said. In addition to innovative gene-vector-promoter constructs and loco-regional ...