To initiate gene transcription, RNA polymerase II (Pol II) requires the transcription factor IIB (B). Here we present the crystal structure of the complete Pol II–B complex at 4.3 Å ...

Transcription of ribosomal RNA by RNA polymerase (Pol) I initiates ribosome biogenesis and regulates eukaryotic cell growth. The crystal structure of Pol I from the yeast Saccharomyces cerevisiae ...

An RNA polymerase II molecule is about 15 nanometers across, or roughly 5,000 times smaller than the width of a human hair. This image was created by reconstructing X-ray diffraction crystallography ...

A team in China led by Zihe Rao at Tsinghua University report the cryo-electron microscopy (cryo-EM) structure of the RNA-dependent RNA polymerase (RdRp), which is a key part of the virus’s ...

Ribonucleic Acid (RNA) polymerase is an intermediary enzyme responsible for processing gene sequences into RNA-based genetic material that can be utilized in protein synthesis. In this article, we ...

"An RNA-dependent RNA polymerase ribozyme is the foundation ... That's what makes this structure so interesting." Robertson and Scott determined the structure of a ribozyme that is not an entirely ...

In RNA viruses, such as coronaviruses ... In addition to targeting the polymerase structure directly, some drugs are proposed that would target the proteases involved in nsp12 production.

The current polymerase thought to be used for the ... This suggests the two RdRp enzymes may keep working in the dimer structure, continuing RNA-dependent processes — although the researchers ...

Ribonucleic Acid (RNA) polymerase is an intermediary enzyme responsible for processing gene sequences into RNA-based genetic material that can be utilized in protein synthesis. In this article, we ...