Conventional targeted RNA-seq methods often require labor-intensive pre-sequencing enrichment steps, which can compromise ...

With a modified polymerase and optimized oligonucleotide chemistry, Helicos' single-molecule sequencer takes on RNA. RNA sequencing (RNA-seq) is actually a misnomer for the increasingly popular ...

Spatial transcriptomics is a cutting-edge technique that characterizes gene expression within sections of tissue, such as ...

In the microscopic world of bacteria, gene transfer is a powerful mechanism that can alter cellular function, drive ...

In this interview, we gain a behind the scenes look at Morgan’s recently published paper in BioTechniques, ‘RNA Extraction and RNA-Sequencing Method for Transcriptomic Analysis of Mycobacterium ...

From bulk and single cell methods to spatial and multiomic methods ... with mRNA and small non-coding RNA sequencing. “The small RNA sequencing was going to take a lot of customization and things that ...

The immune system responds to an infection by producing antibodies that recognize and bind to the cell surface of the ...

An international research team, led by scientists from Tel Aviv University and Sheba Medical Center, has unveiled an ...

Alternative splicing (AS) of pre-mRNA plays a crucial role in tissue-specific gene regulation, with disease implications due to splicing defects. Predicting and manipulating AS can therefore uncover ...

2017 Cell; Li et al 2020 Current Biology). Recently, we developed a single-nucleus RNA-seq method in flies (McLaughlin, …, Li, 2021 eLife) and applied it to the Fly Cell Atlas (FCA) project, a large ...

The lab focus on pancreatic cancer in particular. Development of Quantitative Single-cell RNA-seq methods for Studying Tumorigenesis and Aging processes The quantification of transcriptional variation ...