To do so, a mutant HRAS (a member of the RAS family most common in skin cancers) was induced in individual skin stem cells. The researchers monitored how these cancerous stem cells interact with the ...

This approach has been used extensively in the elucidation of signal-transduction cascades, such as those involving Ras-family proteins. Here I discuss the power and potential pitfalls of using ...

Crucially, we discovered the important oncogene NRAS, and the mechanism by which members of the RAS family of oncogenes cause cells to become cancerous. In the 1980s, two ICR researchers, Professors ...