Increased risk seen in adjusted analyses in association with nucleoside and nucleotide reverse transcriptase inhibitor use.

Clin Drug Invest. 2007;27(8):509-531. Antiretroviral drugs (ARVs) can be divided into four different classes according to their modes of action: nucleoside or nucleotide reverse transcriptase ...

Nucleoside reverse transcriptase inhibitors (NRTIs), and nucleotide reverse transcriptase inhibitors (NtRTIs), often all referred to as NRTIs, work by targeting the action of an HIV protein called ...

Nonnucleoside reverse transcriptase inhibitors (NNRTIs) prevent the conversion of viral RNA to viral DNA in the cytoplasm of human immunodeficiency virus (HIV)-1-infected CD4+ lymphocytes ...

Dual Inhibitor: A compound designed to concurrently inhibit two distinct enzymatic activities, such as the polymerase and RNase H functions of reverse transcriptase or both RT and integrase.

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The genetic encephalopathy Aicardi–Goutières syndrome is thought to be due to misidentification of self-derived nucleic acids and the induction of a type I interferon–mediated response.

Non-nucleoside Reverse Transcriptase Inhibitors (NNRTIs) NNRTIs bind to and disable reverse transcriptase, a protein that HIV needs to make more copies of itself.

Cardiomyopathy with Mitochondrial Damage Associated with Nucleoside Reverse-Transcriptase Inhibitors. Published December 5, 2002. N Engl J Med 2002; 347: 1895-1896. DOI: 10.1056/NEJM200212053472320.

Reverse Transcriptase Inhibitor Fast Tracked for Progressive Supranuclear Palsy. Brian Park, PharmD | Publish Date May 21, 2024 . After 48 weeks of treatment, TPN-101 reduced the levels ...

Treatment with an antiretroviral regimen based on a protease inhibitor magnifies any underlying genetic susceptibility to diabetes for women living with HIV, investigators report in the online edition ...

HIV-1 reverse transcriptase inhibitors have long been central to antiretroviral therapy, effectively impeding the enzyme responsible for converting viral RNA into DNA – a pivotal step in HIV ...