Smad anchor for receptor activation (SARA) is an adaptor protein that presents inactive Smads to the TβRI–TβRII complex to facilitate Smad phosphorylation and transduce the TGFβ signal.
The transcription factor Miz-1 activates the Ink4b promoter, and interacts with Myc and TGF-β-activated Smad proteins. Miz-1 is thus a point of convergence for these antagonistic signals in cell ...
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