Small nucleolar RNA, or snoRNA, identifies the rRNA targets for the addition of a chemical group or for rearrangement. The modifications produce a functional rRNA molecule that works in the ribosome.

Molecules called small nucleolar RNAs (snoRNAs) were isolated from nucleolar extracts because of their abundance in this structure. ... Jabri, E. Non-coding RNA: Small, but in control.

More information: Yujing Cheng et al, A non-canonical role for a small nucleolar RNA in ribosome biogenesis and senescence, Cell (2024). DOI: 10.1016/j.cell.2024.06.019.

Scientists have discovered unexpected functions of small nucleolar RNAs (snoRNAs) ... Hereditary information is stored in DNA, which is accessed through an intermediate form, called RNA.

The main rRNA transcript, which encodes three of the four rRNAs (5.8S, 18S, and 28S), is synthesized by RNA polymerase I and processed in the nucleolus with the use of the small nucleolar RNPs ...

Zhang QY, et al. Small non-coding RNAome changes during human chondrocyte senescence as potential epigenetic targets in age-related osteoarthritis. Genomics. 2023;115(2):110574. Cheng Y, et al. A ...

Next-generation sequencing has moved beyond the confines of genomic samples obtained from heterogeneous tissues and begun to disseminate information at the single-cell level. The information ...

Another class of small non-coding RNA is Piwi-interacting RNA (piRNA). piRNAs represent the most abundant class of small non-coding RNA molecules expressed in animal cells, and these are slightly ...

The development of messenger RNA (mRNA) vaccines against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has only increased the impetus in this field.