Pain isn't just a physical sensation-it also carries emotional weight. That distress, anguish, and anxiety can turn a ...

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More information: Sukjae J. Kang et al, Thalamic CGRP neurons define a spinothalamic pathway for affective pain, Proceedings of the National Academy of Sciences (2025). DOI: 10.1073/pnas.2505889122 ...

The authors further noted, “… there are several neural pathways involved in sensory perception in addition to the anterolateral spinothalamic tract, which our current hASA models.

We found a class of lamina I spinothalamic tract (STT) neurons selectively excited by iontophoretic histamine. The responses of this class of neurons parallel the pure itching sensation this ...

A class of spinothalamic tract neurons is selectively excited by stimuli that cause itch, suggesting that this sensation is mediated by distinct peripheral and central pathways. The best-known ...

It communicates information from many different physiological systems, like heart rate, using a complex set of neural pathways. 11,12 The spinothalamic tract, vagal sensory nerves, and the nucleus ...

Sensory pain was thought to be mediated by the spinothalamic tract, a pathway that sends pain signals from the spinal cord to the thalamus, which then relays them to sensory processing areas ...