"Being able to enhance or increase the frequency of follicular helper T cells may be an excellent approach for better vaccine design." Before B cells can launch a full-blown antibody response ...

The first patient has been dosed in the phase 3 TERZO trial of Copiktra for relapsed or refractory nodal T-follicular helper ...

They found that a specific type of immune cell, called T follicular helper cells, indirectly controls the anti-influenza response. These helper cells often "see" the wrong parts of the virus ...

T follicular helper cells (Tfh) are essential for strong antibody-mediated reactions of our immune system during infections and vaccinations. However, if they get out of control, this can cause ...

These antibody-mediated responses depend on germinal centres (GCs)—anatomical structures inside the B-cell zone—where T follicular helper (Tfh) cells interact with and provide help to B cells ...

T follicular helper cells (Tfh) are essential for strong antibody-mediated reactions of our immune system during infections and vaccinations. However, if they get out of control, this can cause ...

Increased numbers of follicular helper T cells have been observed in patients with rheumatoid arthritis, but the functions of these cells have been unclear. In a new study published in Annals of ...

In mechanistic details, the researchers found that intrinsic IFN-γ-STAT1 signaling in B cells in the germinal center of lung-draining lymph nodes promoted expression of the T-bet transcription factor, ...

Wu is senior author of the team’s paper in Nature Immunology, titled “Aberrant T follicular helper cells generated by TH17 cell plasticity in the gut promote extraintestinal autoimmunity.” ...

In mechanistic details, the researchers found that intrinsic IFN-γ-STAT1 signaling in B cells in the germinal center of lung-draining lymph nodes promoted expression of the T-bet transcription ...