the TP53 pathway, a crucial tumor suppressor mechanism, is influenced by exRNA activity, either promoting or inhibiting tumor progression. The Cyclin-CDK pathway, essential for cell cycle ...

1). BI 907828 binds directly to MDM2 and blocks its interaction with p53, leading to stabilization of p53, TP53 target gene induction, cell-cycle arrest and apoptosis in tumour cells with wild ...