Her data argued that CML cells are dependent on BCR-ABL even at relapse. In theory, one could screen for drugs that inhibit imatinib-resistant BCR-ABL mutants, and these drugs should be effective ...

Notch can function as an oncogene. Aberrant expression of the dominant active cytoplasmic domain of Notch receptors in haematopoietic cells because of chromosomal translocation or viral ...