Bacterial growth and pathogenicity depend on the correct formation of disulfide bonds, a process controlled by the Dsb system in the periplasm of Gram-negative bacteria. Proteins with a thioredoxin ...

The thiol agents bind to similar hydrophobic pockets as the Cys379–Cys432 disulfide, and in fact, Cys432 forms a covalent bond with P2165. This could help hone the agent still further to enhance ...