So far, researchers have developed numerous tools to study the interplay between cells and their 3D microenvironment. One of the most popular technologies is traction force microscopy (TFM).

Three-dimensional traction force microscopy shows where and how hard this bone-like cell is pulling on the surrounding gel. Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of ...

For example, the resolution of this kind of traction force microscopy is about 0.5 micrometers, meaning that deformations smaller than this cannot be measured.

So far, researchers have developed numerous tools to study the interplay between cells and their 3D microenvironment. One of the most popular technologies is traction force microscopy (TFM).

Traction force microscopy. The human body contains about 37 trillion cells. In each tissue, cells are held together by an extracellular matrix -- a network of molecules that includes water, ...

Digital Instrument's BioScope Anyone who has ever taken the time to critically examine a walnut knows that a two-dimensional photograph fails in many respects to truly convey the unique features--the ...

Traction force microscopy. The human body contains about 37 trillion cells. In each tissue, cells are held together by an extracellular matrix—a network of molecules that includes water, ...

They applied 3-D single-cell traction force microscopy, a technique that uses fluorescent beads embedded along with cells in a collagen matrix, to measure that force. While a breast cancer cell pulls ...

When researchers applied deep learning and 3D holographic microscopy to the task, they not only avoided these difficultues but found that AI was better at it than humans were.

We have applied this method to single cells and multicellular constructs cultured in 3D, with a focus on cell-matrix interactions. Beyond this endpoint analysis technique, we also implement ...