and a central projection to the trigeminal nucleus caudalis and its cervical extension, the trigeminocervical complex (TCC). The development of the anti-migraine therapeutics, triptans-5-HT 1B/1D ...

This could be due to general pain hypersensitivity or inflammation spreading from the upper portion of the cervical spinal cord to the trigeminal nerve tract. Other issues of misalignment in the ...