Calcium is required by two proteins, troponin and tropomyosin, that regulate muscle contraction by blocking the binding of myosin to filamentous actin. In a resting sarcomere, tropomyosin blocks ...

a low intracellular calcium ion concentration is maintained and the tropomyosin-troponin complex suppresses interaction between molecular motor myosin and actin filament (F-actin); this is termed ...

The commonly identified myofilament phosphoproteins cardiac troponin I, troponin T, myosin regulatory light ... The abbreviation abLIM1 denotes actin-binding LIM protein 1, AMPK AMP-activated ...

The thin filament consists of F-actin, troponin, tropomyosin, and nebulin. The thick filament is formed of myosin, titin and myosin binding protein C (MyBP-C). The latter can form links between ...

Biomolecular condensates are distinct molecular communities made of DNA, RNA and proteins that "condense" molecules to key ...

The troponin pulls towards tropomyosin, exposing the acting strands. The myosin is now free to attach itself to the exposed actin sites. But it can’t just do this on its own, no, only myosin ...

The thin filament consists of F-actin, troponin, tropomyosin, and nebulin. The thick filament is formed of myosin, titin and myosin binding protein C (MyBP-C). The latter can form links between ...

The cardiac thin filament governs contraction by sensing intracellular calcium levels, with conformational changes occurring at a threshold of pCa 6, enabling myosin-actin cross-bridge cycling and ...

Over the last several years the identification and functional characterization of the motor proteins actin and myosin in the nucleus has initiated a change in the view of nuclear processes. It is now ...

Their work, published in Nature Communications, reveals a mechanism of interdependence of different forms of the cytoskeletal proteins actin and myosin, and their functions. The team also ...