Muscle contraction and many other movement processes are controlled by the interplay between myosin and actin filaments. Two further proteins, tropomyosin and troponin, regulate how myosin binds ...

Tropomyosin is a long protein that associates with actin, a highly conserved thin filament protein found in organisms from yeast to humans. Actin, a major part of the cell's cytoskeleton, drives ...

Cardiac contraction occurs when calcium binds the troponin complex (subunits I, C, and T) and α-tropomyosin and releases the inhibition of myosin–actin interactions by troponin I. ATPase ...

a low intracellular calcium ion concentration is maintained and the tropomyosin-troponin complex suppresses interaction between molecular motor myosin and actin filament (F-actin); this is termed ...

The calcium then binds to a protein called troponin, and that triggers the "flexing movement" of alpha-tropomyosin, which allows another protein called myosin -- the motor protein -- to interact ...

Mutations in actin, troponin (Tn) and tropomyosin (Tpm), especially in TnT, have been linked to these diseases. Despite the known association between TnT mutations and cardiomyopathies, detailed ...

The thin filament consists of F-actin, troponin, tropomyosin, and nebulin. The thick filament is formed of myosin, titin and myosin binding protein C (MyBP-C). The latter can form links between ...

35% of genetic cardiomyopathies are due to mutations in the cardiac thin filament. Composed of actin, tropomyosin (Tpm), and troponin (Tn), the thin filament is a part of the regulatory mechanism of ...