This is a major debate in this field: whether BAP1 functions as a tumor suppressor or oncogene ... increased the expression ...

For instance, one recent study reported a synonymous mutation in the tumor suppressor gene BAP1 in a patient with a severe form of kidney cancer. The mutation likely causes the splicing machinery to ...

Tumor suppressor genes act as “brakes” to stop cells before they can travel down the road to cancer. A loss of function mutation in these genes can be disastrous. Like all genes, tumor ...

The BAP1 protein is a powerful tumour suppressor protecting against cancers of the eye, lung lining, brain, skin and kidney. A malfunction in the gene fuels cancer growth and while this has been a ...

Identification of genes inactivated by promoter CpG methylation is a powerful approach to discover novel tumor suppressor candidates. PCDH10suppresses gastric cancer cell growth through cell ...