Scientists have recently shed some light on exactly why elephants, one of the biggest animals on the planet, paradoxically ...

When they lose function, cancer is left to grow. The most important tumor suppressor is the protein p53. The gene coding p53 is mutated in about 40 percent of all cancers, and the remaining ...

The p53 tumour-suppressor gene integrates numerous signals that control cell life and death. As when a highly connected node in the Internet breaks down, the disruption of p53 has severe consequences.

One of the most interesting methods of activating p53 results from the mutational inactivation of a tumor suppressor gene like the retinoblastoma protein (which activates the E2F-1 transcription ...

"The p53 gene is the guardian of the genome because it signals the cell to repair DNA damage when that occurs. If we can find genetic or environmental risk factors that lead to damage of p53 or ...

Cancer Related Gene P53 Not Regulated As Indicated By Previous Tissue Culture Research Date: June 28, 2005 Source: Salk Institute Summary: The cellular cascade of molecular signals that instructs ...

By using a genetic variant of p53 and comparing what that variant failed to accomplish with what the healthy “wild type” p53 gene could do, the researchers discovered the mechanism by which ...

The p53 gene is one of the most important in the human genome: the only role of the p53 protein that this gene encodes is to sense when a tumor is forming and to kill it. While the gene was ...

The gene p53 has long been a target of intense research in the oncology community because in its unaltered form it suppresses cancer. Mutations in p53 are known to promote the formation of several ...

The p53 gene is extremely important in cell biology as its role is to regulate the cell cycle and halt the formation of tumors, leading to its nickname the “tumor suppressor gene.” However ...

The well-known cancer gene, p53, which researchers had thought was less relevant in kidney cancer, may play an important role after all – a discovery that could potentially lead to new treatments.