Statins have pleiotropic effects, ie the ability to reduce heart disease risk and CV death via an unknown mechanism, certainly beyond the LDL cholesterol lowering that they can achieve.

The phenotypic effects that single genes may impose in multiple systems often give us insight into the biological function of specific genes. Pleiotropic genes can also provide us valuable ...

Fenofibrate and atorvastatin have multidirectional pleiotropic effects on MS patients. Isolated fasting glucose (IFG) and impaired glucose tolerance (IGT) patients greatly benefit from statin and ...