Deoxyribonucleic acid (DNA) replication is fundamental to life, yet the precise mechanics of how helicases unwind the genome for replication remain unclear. A recent study published in Nature used ...

For patients with cancers harboring certain genetic defects, the first-in-class targeted therapy RO7589831, which targets the ...

How does the cell protect these strands from damage? How would you identify the protein that serves as a connector between DNA helicase and pol-a/primase? A simple yet often effective approach is ...

Nimbus Therapeutics announced the launch of a first-in-human clinical trial for NDI-219216, its investigational Werner ...

RO7589831, a new drug from Roche, is first in a new class of drugs called Werner helicase inhibitors Drug works similarly to other DNA damage repair inhibitors, such as PARP inhibitors This class ...