Yeast has proven a valuable model system to understand eukaryotic transcription mechanisms. Extending the vale of the system even further, several investigators have attempted to express mammalian ...

Kobe University bioengineers describe three design principles for efficient and reliably controllable yeast promoters, the genetic switches that regulate the artificially introduced genes ...

The study revealed that almost all genes have the same kind of structure where ... of how human cells work. These promoter nucleosomes are the only ones in the yeast DNA that contain in their ...

Since the discovery of DNA's double helical structure more than a half ... When the investigators tested their model on real promoters in the genome of yeast, they confirmed that it could ...

As much as biologists know about the structure and ... strengths of the two promoters, essentially creating a genetic timer. The researchers engineered this network into yeast so that when the ...

the scientists found that most regions of the yeast genome produce several transcripts starting at the same promoter. These transcripts are interleaved and overlapping on the DNA. In contrast to what ...

Their goal was to pinpoint the optimal combination of D-lactate dehydrogenase (D-LDH) genes and promoters in K. phaffii that would maximize the yeast's ability to produce D-lactic acid from methanol.

The most widely used organism is the yeast Pichia pastoris (now called Komagataella phaffii). “It contains a unique promoter – a specific gene region which can be activated by methanol.