If damage in the rDNA is not accurately repaired, it can lead to chromosomal rearrangements and cell death. In organisms from yeast to worms to humans, nucleoli expand during aging.

If damage in the rDNA is not accurately repaired, it can lead to chromosomal rearrangements and cell death. In organisms from yeast to worms to humans, nucleoli expand during aging.

If damage in the rDNA is not accurately repaired, it can lead to chromosomal rearrangements and cell death. In organisms from yeast to worms to humans, nucleoli expand during aging.

Thus, the team began this current study with a scavenger hunt for a nucleosome-modifying enzyme which could perhaps reposition nucleosomes relative to MCM and thereby modify the timing of rDNA ...

These mother cells, which, in typical yeast fashion, would bud off to form daughter cells, were then monitored for levels of rDNA silencing (an indicator of nucleolus aging) and heme abundance (an ...

If damage in the rDNA is not accurately repaired, it can lead to chromosomal rearrangements and cell death. In organisms from yeast to worms to humans, nucleoli expand during aging.