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Keeping a cell's nucleolus compact may be key to fighting aging
If damage in the rDNA is not accurately repaired, it can lead to chromosomal rearrangements and cell death. In organisms from yeast to worms to humans, nucleoli expand during aging. On the flip ...
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Humans Have a Secret ‘Mortality Timer’ That Could Delay Aging, Scientists Say
Because rDNA encodes the RNA portions of ribosomes ... a postdoctoral fellow at Weill Cornell Medicine—analyzed the nucleolus of yeast, which was used as a model organism because its inner ...
Nature9mon
Diverse and dynamic functions of the Sir silencing complex
The yeast Sir protein complex has been implicated ... Loss of Net1p results in slow growth and loss of rDNA silencing, and Net1p has been linked to the Cdc14 phosphatase and progression of the ...