“But the idea that you could amplify a specific targeted DNA sequence using an oligonucleotide primer and DNA polymerase was not at all obvious.” Erlich led the team of scientists at the Cetus ...

These oligonucleotide primers delimit the region that will be amplified. To begin PCR amplification, the enzyme is added to the primed template DNA and incubated so that it synthesizes new ...

To facilitate allele discrimination in genomic DNA, we designed a second oligonucleotide primer to bind specifically to the tandem DNA generated by RCA of the gap-fill probe. This primer ...

The dual biotin group is essential to keep the oligonucleotide attached to the streptavidin-coated beads during thermal cycling 4,5. Primers 5 and 6 are unmodified oligonucleotides with the Tag1 ...

(6) Continued exposure to harsh chemicals damages the DNA and reduces yields. Scientists use short oligonucleotides as primers for polymerase chain reaction and next-generation sequencing, in DNA ...

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