The San Francisco 49ers and the Dallas Cowboys are bringing the hype for their showdown at Levi's Stadium.

The 49ers are riding a tow game losing streak into Week 17. They are poised to increase it to three in their matchup with the Lions. Here are three reasons why the 49ers will lose to the Lions.

Either way, we’ll likely hear their names often on Monday Night Football, as one of those newcomers will be protecting 49ers’ quarterback Brock Purdy’s blindside against the Lions.

San Francisco 49ers running back Isaac Guerendo is expected to play Monday night against the Detroit Lions, according to ESPN's Adam Schefter. More news: Titans Reveal RB Tony Pollard's Playing ...

Charvarius Ward will join the list of 49ers missing Monday night’s game against the Lions at Levi’s Stadium after the team ruled him out Sunday afternoon. The veteran cornerback and his ...

The Detroit Lions and San Francisco 49ers have released their final injury reports of the week ahead of their Monday night showdown in Week 17 and there are a total of six players ruled out and ...

The San Francisco 49ers today announced that the team has signed OL Matt Hennessy to a two-year deal and OL Sebastian Gutierrez to the team's practice squad. In order to make room on the roster ...

The Detroit Lions and San Francisco 49ers met 11 months ago at Levi's Stadium with a trip to the Super Bowl on the line. San Francisco used a furious second half comeback to steal the NFC ...

Quarterback Brock Purdy completed 26-of-40 passing attempts for 313 yards and two touchdowns with a passer rating of 95.1. Purdy's passing touchdowns gave him 17 this season and 61 in his career ...

The San Francisco 49ers are prepping for Week 17 against the Detroit Lions on Monday Night Football. What they're not prepping for is a playoff push in January. At 6-9, Kyle Shanahan and the 49ers ...