Early dysfunction of the endothelial/blood-brain barrier (BBB) is involved in the pathogenesis of cerebral small vessel disease (SVD), which is a contributor to about 50% of dementias.

Aston Martin Lagonda Global Holdings Plc designs, creates, and exports cars. Its sports cars are manufactured in Gaydon with its luxury DBX SUV range manufactured in St. Athan, Wales. The company ...

The evolution of a disease resulting in functional changes in your body is known as pathophysiology. To understand COPD’s pathophysiology, it’s important to understand the structure of the ...

FGF receptors (FGFRs) are involved in the pathogenesis of cancer and skeletal disorders. Experiments in model systems have shown that FGFR-specific inhibitors may be valuable in treating multiple ...

ALL = Acute lymphoblastic leukemia; AML = Acute myeloid leukemia; FTI = Farnesyltransferase inhibitor; HDAC = Histone deacetylase; NF = Nuclear factor; Ph = Philadelphia chromosome; TKI = Tyrosine ...

The Solicitors Regulation Authority has exercised its fining powers fully by issuing a financial penalty of £25,000 to a firm for AML breaches. The regulator announced the fine – the maximum it ...

Acute myeloid leukemia (AML) is an aggressive hematological malignancy; it is the most common acute leukemia in adults. AML prognosis is often poor, and relapse often occurs after initial remission.

There are some key differences that set CLL apart from other types of leukemia, such as ALL (acute lymphocytic leukemia), AML (acute myeloid leukemia), and CML (chronic myeloid leukemia).

About 22,010 people will be diagnosed with AML. Most cases will be in adults. About 11,090 people will die from AML. Again, most of these deaths will be in adults. AML accounts for about 1 out of 3 ...

These findings warrant further exploration into the mechanisms by which SDF-1α contributes to AML pathophysiology and treatment outcomes. Moreover, prospective clinical trials are needed to validate ...