Figure 1: Model of Spir and Cappuccino cooperation in actin nucleation/polymerization. Together these findings establish actin nucleation by multiple WH2 domains as a general mechansim.

GAS2 is a cytoskeletal regulator that interacts with both F-actin and microtubules. Here, cryo-EM structures of GAS2 domains ...

These are members of a team from Rice University and Baylor College of Medicine that deciphered the 3-D structure of actin nucleation, a critical but fleeting process that takes place thousands of ...