Key mediators underlying these effects are shown. The fate of activated stellate cells during resolution of liver injury is uncertain, but may include reversion to a quiescent phenotype and/or ...

Stellate cell "activation" is a key event in liver injury, and refers to the ... Cells with features of both quiescent and activated states are often called "transitional cells." ...

jpi{at}soton.ac.uk BACKGROUND Activated hepatic stellate cells (HSC) are central to the pathogenesis of liver fibrosis, both as a source of fibrillar collagens that characterise fibrosis and matrix ...

az.vub.ac.be Accumulating evidence suggests that stellate cells are involved in the regulation of the liver microcirculation and portal hypertension. Activated hepatic stellate cells have the ...

Hepatic macrophages can interact with hepatocytes, hepatic stellate cells, and endothelial cells ... Upon detecting abnormalities in the body, KCs become activated and transmit signals to activate ...

Myofibroblasts (MFBs) proliferation is the core event of fibrosis. In the liver, activated hepatic stellate cells (HSCs) are the main source of MFBs. ROS is closely related to HSCs activation, and ...

Activated hepatic stellate cells adopt a myofibroblast phenotype and increase production and deposition of ECM components leading to liver fibrosis which can eventually progress to liver cirrhosis. Up ...

A guardian molecule ensures that liver cells do not lose their identity. This has been discovered by researchers from the ...

Researchers from the University of Illinois have identified a key process coordinating liver maturation and polyploidization, ...