Activated hepatic stellate cells adopt a myofibroblast phenotype and increase production and deposition of ECM components leading to liver fibrosis which can eventually progress to liver cirrhosis. Up ...
A recent study evaluated the possible direct antifibrogenic effects of canrenone, the active metabolite of spironolactone, in activated human hepatic stellate cells -- it reduced in a dose ...
The body produces millions of red blood cells each day in the bone marrow. They circulate around the body for about 120 days, then go to the liver and spleen, which destroy them and recycle their ...
A recent study from Tata Institute of Fundamental Research, Mumbai, India has revealed new details about how our cells clean up and recycle waste. This process, known as autophagy, is like a self ...
In 2009 a team of biophysicists led by Anthony A. Hyman of the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, Germany, were studying specklelike structures called P ...
abrogate the ability of previously activated CD8 effector T cells to kill target cells, and induce exhaustion of T cells. Thus, LSEC, the most abundant NPC in the liver, play a key role in regulating ...
Metabolic requirements of dividing hepatocytes are prerequisite for liver regeneration after injury. In contrast to transcriptional dynamics during liver repair, its metabolic dependencies remain ...
2Department of Cell Biology, Zhejiang University School of Medicine, Hangzhou, China. 3Cancer Center, Zhejiang University, Hangzhou, China. Search for other works by this author on: 1Children’s ...
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