Key mediators underlying these effects are shown. The fate of activated stellate cells during resolution of liver injury is uncertain, but may include reversion to a quiescent phenotype and/or ...

The identification of activated hepatic stellate cells (HSCs) as the major fibrogenic cell type in the injured liver, as well as the recognition of key cytokines involved in this process ...

Once activated, HSCs undergo a process of transdifferentiation ... Mechanisms of Epigenetic Regulation in the Fibrogenic ...

This buildup of collagen and other fibrous tissue accelerates when hepatic stellate cells become activated during hepatitis, often resulting in liver cancer or cirrhosis, both of which can be fatal.