Alpha-1 adrenergic receptors (α1-ARs) are a subset of G protein-coupled receptors that play a pivotal role in cardiovascular homeostasis. While traditionally recognised for their involvement in ...

Study met its primary and key secondary endpoints, demonstrating rapid and sustained improvement in near visual acuity; Safety profile consistent with previous clinical trials and ...

CONCLUSIONS These data confirm that alpha-adrenergic receptors are widespread in the coronary microcirculation, with the baseline functional responses to alpha 1-adrenergic activation predominating in ...

Blockade of alpha 1-adrenergic receptors does not prevent this sensitization, demonstrating that it occurs independently of alpha 1-adrenergic receptor activation. Only blockade of protein kinase C by ...

The crystal structure of a second G protein–coupled receptor sheds light on these key pharmaceutical targets.

Third-generation α 1-adrenergic antagonists are pharmacologically uroselective in that they are competitive antagonists for prostatic α 1A-receptors. [16,17] Blockade of these receptors relaxes ...

Tamsulosin is the most commonly prescribed α-1 adrenergic receptor blocker for the management of benign prostatic hyperplasia (BPH) in aging males. [1, 2] The drug has a selective action on the ...

The selected reduced target molecules are validated to perform as α 1 -adrenergic receptors antagonists. The most potent one, 4bh, exhibits an IC 50 value of 277 nM on α 1A subtype with a selectivity ...

Objectives We aimed to synthesise the available data for the effect of stopping alpha-blocker therapy among men with lower urinary tract symptoms. The focus was on symptom, uroflowmetry and quality of ...

The combination of a β-adrenergic receptors (AR) blocker and a carbonic anhydrase (CA, EC 4.2.1.1) inhibitor in eye drops formulations is one of the most clinically used treatment for glaucoma. A ...

Estrogen regulates the amount of white adipose tissue (WAT) in females, but its role in males and whether WAT effects involve estrogen receptor-α ...