More importantly, this mechanism is not limited to a specific type of ataxia but extends across ataxias of various etiologies." More information: Chih-Chun Lin et al, Reduced cerebellar rhythm by ...

The primary cellular events and mechanisms underlying the disease are unknown. We found that mice lacking cystatin B develop myoclonic seizures and ataxia, similar to symptoms seen in the human ...

Since reducing oxidative stress and mitochondrial dysfunction rather than reversing Friedreich's ataxia symptoms is the mechanism of action for vatiquinone, the agency might want more long-term ...

Our goal is to decipher how genetic alterations perturb the balance of excitation and inhibition in the brain, impact cerebro-cerebellar circuits in autism and ataxia, impact neural development across ...

Neuronal atrophy early in a mouse model of spinal cerebellar ataxia 1 may represent an adaptive mechanism that restores the density of potassium channels in Purkinje neurons, thus normalizing ...

Yoda Therapeutics Inc. (YODA), an AI-driven company that focuses on Central Nervous System (CNS) drugs, today announced the dosing of the first patient in the Phase 2 trial of YA-101 for Multiple ...