During autophagy, cells wrap damaged or degraded cells in bilayer membrane structure autophagy vacuoles, which are then transported to lysosomes for degradation, releasing amino acids and metabolites ...

During starvation-induced autophagy, ATG2A undergoes depalmitoylation as the balance between ZDHHC11-mediated palmitoylation and APT1-mediated depalmitoylation. Inhibition of ATG2A depalmitoylation ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Targeting Tyrosyl-DNA phosphodiesterase 1 ...

National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei 230026, China Department of Pathology, The First Affiliated Hospital of USTC, Division of Life Sciences ...

Its pathological features include: A lot of misfolding and abnormal aggregation of amyloid protein (Aβ); Autophagy disorder, oxidative stress, neuroinflammation, abnormal phosphorylated tau protein ...

Division of Multi-Organ Transplantation, Department of Surgery, University of California, San Francisco, United States; Bakar Computational Health Sciences Institute, University of California, San ...