Sensitivity to ionizing radiation is compelling evidence that BRCA1-and BRCA2-deficient cells are defective in repair of DSBs. As discussed above, 2 separate pathways play major roles in DSB repair in ...

As a young breast cancer survivor with a BRCA1-positive diagnosis, I faced tough choices. Ultimately, I chose to undergo a laparoscopic prophylactic oophorectomy, a decision rooted in my ...

Furthermore, depletion of PIAS1 and PIAS4 causes a decrease in DSB repair by homologous recombination ... is mediated by the E3 ubiquitin ligases BRCA1, RNF8 and RNF168. Galanty et al.

Mutations in the BRCA1 gene that are either inherited (germline) or acquired (somatic) might not be key to the initiation of prostate cancer, as previously thought, suggests the first study of its ...

Among patients with early-stage triple-negative breast cancer, a beneficial pathologic complete response rate was higher in patients with BRCA1/2 mutations. Among patients with early-stage ...