The brain on drugs Drugs elevate CREB activity in the nucleus accumbens by activating cyclic AMP pathway, causing protein kinase A to translocate to the nucleus and phosphorylate CREB. Target genes ...

Research on the biological basis of addiction has found that the critical epigenetic enzyme histone deacetylase 5 (HDAC5) limits the expression of the gene Scn4b, regulating neuronal activity and ...

Getting therapeutic drugs past the blood-brain barrier has long been a major challenge in treating brain diseases. Now, researchers have explored how cholesterol-modified heteroduplex oligonucleotides ...

By combining insights on specific gene targets, brain regions linked to aging, and existing clinical trial data, the ...

By targeting areas of the brain responsible for reward signals from food, GLP-1 drugs might also reduce the rewards people get from other things, such as addictive substances. But what does the ...