Agonists of the type 1 cannabinoid receptor (CB1) show promise as alternative analgesics but are still limited by side effects and tolerance. Reporting in Nature, Rangari et al. apply computation ...

Here, we explored how NMDARs signal in tLTD. We found that, regardless of frequency, L5 PC→PC tLTD relies on the non-ionotropic preNMDAR signaling pathway mediated by JNK2, which helps to resolve the ...

GluA2, one of the primary subunits of AMPARs, has long been thought to prevent calcium permeability when included in the receptor complex. Results indicate that the R607E and R607G missense ...

Chief Scientific Officer Dr. Chris Twitty highlighted the significance of nimacimab’s differentiated mechanism, which may maintain efficacy even when the CB1 receptor and its natural ligands are ...

It comprises endocannabinoids (naturally produced compounds), receptors (CB1 and CB2), and enzymes that synthesize and degrade these compounds. THC and CBD: The Dynamic Duo Cannabis contains over ...

Nimacimab is a humanized IgG4 negative allosteric modulating antibody that specifically binds to the CB1 receptor with no cross-reactivity to other G-protein-coupled receptors, including ...

“This new preclinical study highlights that a truly peripherally-restricted CB1 inhibitor—nimacimab—effectively drives weight loss in a DIO model. Nimacimab compared favorably to and ...

The acquisition will add SKNY-1 to Mira’s pipeline. Mira said the oral candidate is “designed to interact with cannabinoid receptors CB1 and CB2 pathways.” Interest in treating smoking and ...

CB1 receptors: When certain cannabinoids bind with these receptors, they may help relieve pain. CB2 receptors: Animal and laboratory studies suggest that when specific cannabinoids bind to CB2 ...

Brian Kelly and the LSU Tigers wrapped up Day 10 of Spring Camp on Thursday morning with the program getting back out on the practice fields in Baton Rouge. Kelly's crew continues working through ...