1The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada.

Glioblastoma constitutes about half of all primary brain tumors and has a median survival time of 10 to 18 months with current standard treatment of maximal primary resection, irradiation, and ...

The chemokine receptors CCR5 and CXCR4 are the two major coreceptors for HIV entry. Numerous efforts have been made to develop a new class of anti-HIV agents that target these coreceptors as an ...

Today, shares of CytoDyn Inc. (OTCQB: CYDY) are on a tear as the biotechnology company developing leronlimab, a CCR5 antagonist with the potential for multiple therapeutic indications, announced ...

Results: Plasma CCL5 was causally associated with breast cancer in the MR analysis, which was significant in the luminal and HER-2 enriched subtypes and further confirmed using PRS analysis (OR = 0.94 ...

This study is important, and the findings add substantially to the evidence base regarding CCR5 antagonist drugs for neuroprotection and stroke management. The authors adhered to the expected ...

Background: Domestication of wild boars into local and intensive pig breeds has driven adaptive genomic changes, resulting in significant phenotypic differences in intestinal immune function. The ...

Together, these results suggest a unique trafficking capability of CD8 + CCR4 + T cells in patients with AS mediated by the upregulation of CCR1, CCR5, CX3CR1 and CD62L. Our study reports a CD8 + T ...