Among 18 human chemokine receptors, CCR1, CCR4, CCR5, and CCR8 were activated by metal ion Zn(II) or Cu(II) in complex with 2,2′-bipyridine or 1,10-phenanthroline with similar potencies (EC50 from 3.9 ...

This prompted us to investigate whether ccr1 mutants are also affected in nodulation, pointing to a common regulatory mechanism governing both nodule formation and cluster root development. Both the ...

These include the CCR1 receptor, which has been shown to play an important role in multiple sclerosis." The DKFZ researchers' discovery opens up new therapeutic perspectives.

To explore the effect of a rat anti-mouse CC-chemokine receptor-3 (CCR3) monoclonal antibody (CCR3 mAb) on airway eosinophilia and mucus overproduction in asthmatic mice. An asthma model was ...