The inhibition of glutaminase 1 (GLS1) represents a potential treatment of malignant tumors. Structural analysis led to the design of a novel series of macrocyclic GLS1 allosteric inhibitors. Through ...

Coreceptor CCR5 antagonists, which provide a novel mechanism of action, are a recent addition to the armamentarium of antiretroviral agents. Maraviroc (Selzentry, Pfizer Inc., ...

Metalloproteins play crucial physiological roles across all domains of life, relying on metal ions for structural stability and catalytic activity. In recent years, computational approaches have ...

Long working hours might not just be bad for you, they could also be altering the structure of your brain, a new study suggests. The research was conducted by two scientists at South Korea’s ...

CCL5 binding to glycosaminoglycans on the cell surface or in the extracellular matrix sequesters CCL5, thereby immobilising CCL5 to provide a directional signal.33 This may explain why increased ...

To test whether the lack of IL‐17R or IL‐17Rh1 binding to IL‐17F could be the result of immobilization‐linked inactivation, IL‐17F/receptor binding was tested in competition experiments. In these ...

Interscapular brown adipose tissue (iBAT) is a specialized tissue critical for non-shivering thermogenesis and energy expenditure. It generates heat by harnessing the mitochondrial electrochemical ...

RNA-binding proteins (RBPs) play a crucial role in the post-transcriptional regulation of RNAs. Identification of RBP binding sites is a key step to understand the biological mechanism of ...

Platelet structure and anatomy Platelets are made in your bone marrow. These are the smallest types of blood cells, with each one living approximately 7 to 10 days .

An attorney by training, Barrett has been the CEO of ASGCT since 2016. He told GEN that he has had the “fortunate and unique position to see gene therapy go from pre-approval status to in the ...