C&EN14d
Protein Carrier Adeno-Associated Virus
We were able to successfully package three different proteins: Streptococcus pyogenes Cas9 (spCas9), Cre recombinase ... containing at least one GFPnb-modified subunit. Western blot analysis of input ...
eLife22d
The robust, high-throughput, and temporally regulated roxCre and loxCre reporting systems for genetic modifications in vivo
(I) Western blotting of β-Catenin and GAPDH in sorted tdT + cells ... (C) A schematic showing experimental strategy 2 to test mCre/tdT expression by AAV8-TBG-Cre. (D) Immunostaining for tdT on tissue ...
eLife19d
Dilated cardiomyopathy-associated RNA Binding Motif Protein 20 regulates long pre-mRNAs in neurons
Western blot probing RBM20 expression in olfactory bulb and cortex ... Viruses used were rAAV2-CAG-DiO-eGFP or rAAV2-SYN-Cre virus, driving cre-dependent eGFP expression from the chicken beta actin ...
GlobeSt3d
CRE Lending Sees Rebound in Originations But Office Defaults Surge
A recent Trepp research paper examined bank CRE loan performance in the last quarter of 2024. It was a good, bad, and kind of ...
EurekAlert!7d
Inhibiting sphingosine-1-phosphate receptor 3 (S1pr3) mitigates pulmonary fibrosis
(C, D) Quantitative reverse transcription-PCR and Western blot analyses of S1pr3, fibronectin, and collagen I of lung homogenates. BLM, bleomycin; D0, normal control; D3/D7/D14, 3/7/14 days after ...
EMBO Press5d
HAND1 level controls the specification of multipotent cardiac and extraembryonic progenitors from human pluripotent stem cells
How cardiac cell fates are specified during heart development remains elusive. This study identifies a level-dependent role ...
AHA/ASA Journals4d
Lymphatic Endothelial Branched-Chain Amino Acid Catabolic Defects Undermine Cardiac Lymphatic Integrity and Drive HFpEF
BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) has become the most prevalent type of heart failure, but ...
Wall Street Journal20d
Inside the Chinese Region That Has Become a No-Go for Western Companies
URUMQI, China—About a decade ago, some Western companies answered Beijing’s calls to invest in Xinjiang, an underdeveloped region in the country’s remote west. Some were drawn by the natural ...