While CRISPR-Cas9 can accelerate the process of making knockout cell lines, researchers must sometimes make and screen many variations of the genetic scissors to find one that works well.

CRISPR construct to genetically ablate the GABA transporter GAT3 in the mouse visual cortex, with effects on population-level neuronal activity. This work is important, as it sheds light on how GAT3 ...

A Ph.D. student in biomolecular engineering at the University of California, Santa Cruz, has built a software program ...

A comprehensive study headed by researchers at Sanford Burnham Prebys has shown that gene editing—specifically gene knockout (KO)—using CRISPR-Cas9 technology can favor cells with mutated ...

CRISPR is revolutionizing medicine by enabling precise DNA edits, treating genetic diseases like sickle cell anemia and ...

CRISPR-Cas9 is considered a revolutionary gene editing tool, but its applications are limited by a lack of methods by which it can be safely and efficiently delivered into cells. Recently, a ...

New research has found a novel target with therapeutic potential for metastatic eye melanoma—an aggressive eye cancer—with ...

The incorporation of CRISPR/Cas9 into clinical settings has promising applications for the future treatment of genetic disorders, human immunodeficiency virus (HIV) infection, and various ...

This niche discovery has spurred an entire biotech revolution of its own. In animal and plant cells, cutting DNA with CRISPR-Cas9 allows us to turn some genes off and to turn others on.