Although only transiently expressed, the pre-BCR marks an important checkpoint in B-cell development and regulates diverse processes, such as proliferation, allelic exclusion of the second heavy ...

Mechanistically, bioenergetic assays and rescue experiments showed that mubritinib targets complex I of the electron transport chain, thereby impairing BTSC self-renewal and proliferation. Gene ...

Nearly 60,000 people are diagnosed with oral cancer in the U.S. every year, according to the American Cancer Society, and the ...