A recent high-throughput study shows that some types of cancer are associated with mutations in a specific proto-oncogene or in a specific pair of proto-oncogenes (Thomas et al., 2007).

We previously introduced the concept of 'oncogene addiction' to explain how some cancers that contain multiple genetic, epigenetic, and chromosomal abnormalities are dependent on or 'addicted' to ...

Nevertheless, many of the modern strategies described below have been instrumental in making strides towards understanding both types of genetic changes. In contrast to the first oncogenes that ...