EurekAlert!4d
Anti-metastatic potential of OR3 pigment from Streptomyces coelicolor JUACT03 on MDA-MB-231 breast cancer in vitro and in vivo
In this study, the anticancer mechanism was analyzed in MDA-MB-231 cells using MTT, lactate dehydrogenase, caspase, DNA fragmentation, clonogenic, flow cytometry, Western blot, and scratch assays.
News Medical on MSN3d
Inhibition of tumor xenograft growth in mice without systemic toxicity
The management of breast cancer involves various therapeutic approaches. However, many current anticancer treatments indiscriminately damage both cancerous and healthy cells. In cancer treatment, ...
Medscape4d
The Concurrent Chemoradiation Paradigm-General Principles
Summary and Introduction Clinical Application—Disease Entities Theoretical Framework for Therapy−The 'Steel Paradigm' Conclusion References Theoretical Framework for Therapy−The 'Steel ...
eLife3d
CDK-mediated phosphorylation of PNKP is required for end-processing of single-strand DNA gaps on Okazaki fragments and genome stability
Polynucleotide kinase phosphatase (PNKP) has enzymatic activities as 3′-phosphatase and 5′-kinase of DNA ends to promote DNA ligation and repair. Here, we show that cyclin-dependent kinases (CDKs) ...