Patients with cancer aged 65 years and older receiving immune checkpoint inhibitors (ICIs) derive similar clinical outcomes as younger patients, according to a study published online April 21 in ...

The IL-12 cytokine factories, combined with checkpoint inhibitors, successfully eliminated local and distal tumors in preclinical models of metastatic melanoma and colorectal and pancreatic cancers.

The IL-12 cytokine factories in combination with checkpoint inhibitors successfully eliminated local and distal tumors in preclinical models of metastatic melanoma and colorectal and pancreatic ...

Conclusions Inflammatory cytokines suppress RA FLS HDAC5 expression ... or the development of HDAC inhibitors not affecting HDAC5 activity, may have therapeutic applications in RA treatment.

Interest in cytokine modulation has expanded further with the success of interleukin (IL) inhibitors, as well as inhibitors of kinases involved in signalling downstream of cytokine receptors ...