This article examines viral and non-viral vectors in gene therapy, highlighting their mechanisms, advantages, and limitations ...

The LNP-mRNA modality is a novel approach that uses lipid nanoparticles to deliver messenger RNA into cells. The mRNA acts as ...

VectorBuilder's partner, Ucello, announced that its CD19-targeting umbilical cord blood-derived allogeneic CAR-T cell therapy, UC101, received Investigational New Drug (IND) approval from the U.S.

By creating gene editors not found in nature, or optimizing existing editors, AI can improve the accuracy, effectiveness, and accessibility of gene editing.

Cell line development plays a pivotal role in the manufacturing of therapeutic proteins, vaccines and other biologics.

Key Laboratory of Bio-chemistry Engineering - The State Ethnic Affairs Commission-Ministry of Education, Dalian Nationalities University, Dalian, China. State Key Laboratory of Fine Chemicals, Dalian ...

The amount of DNA used for lipofection was 1 μg per well. Transfection efficiency was always higher than 90% as determined by fluorescent microscopy or flow cytometry, following the delivery of a ...

Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi’an 710069, Shaanxi, PR China ...

But to perform Pfunkle or nicking mutagenesis, one needs to ensure high-quality circular DNA and careful design of the primer ... factors in scaling mutation libraries is transformation (transfection ...

Comparison of that ancient DNA with modern human DNA showed that the two species had interbred and that people today still carry the genetic fingerprint of that intermixing. Since then ...