Building proton beam user facilities, especially deciding beam energy level, depends on the attached proton accelerator and users' needs. To adjust beam energy level, two methods are generally used.

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MDM2, a key negative regulator of the tumor suppressor p53, has emerged as a compelling therapeutic target in human cancer. This Viewpoint summarizes the discovery of a potent and orally bioavailable ...

The firm identified Kymera’s wholly-owned STAT6 degrader KT-621 as the primary focus of its investment thesis, with Phase 1b atopic dermatitis data for the compound expected in the fourth quarter of ...

ARV-110 is a first-in-class, oral PROteolysis TArgeting Chimera (PROTAC) protein degrader that selectively targets the androgen receptor and, in phase 1 trials, has demonstrated clinical activity in ...

These results highlight the potential of APH02174 as a highly selective and orally bioavailable IRAK4 PROTAC degrader in the treatment of inflammatory diseases mediated by IRAK4 signaling.

Hepatocellular carcinoma cells impair T-cell activity by consuming lysine, which can be targeted with SLC3A2 inhibition or lysine supplementation as a therapeutic strategy to enhance antitumor ...