eLife4d
Ezh2 Delays Activation of Differentiation Genes During Normal Cerebellar Granule Neuron Development and in Medulloblastoma
Using an unbiased approach, this important study discovered a role of Ezh2 in the differentiation of granule neuron precursors, the cell of origin for Shh group of medulloblastoma. Furthermore, the ...
eLife2d
Generative modeling for RNA splicing predictions and design
Alternative splicing (AS) of pre-mRNA plays a crucial role in tissue-specific gene regulation, with disease implications due to splicing defects. Predicting and manipulating AS can therefore uncover ...
Universal RNA barcoding system for tracking gene transfer in bacteria created
In the microscopic world of bacteria, gene transfer is a powerful mechanism that can alter cellular function, drive ...
Nature5d
RNA sequencing articles from across Nature Portfolio
This isoform-centric microglia genomic atlas includes 35,879 novel human microglia isoforms identified by long-read RNA sequencing. A multi-ancestry quantitative trait locus meta-analysis of known ...
Nature4d
RNA vaccines articles from across Nature Portfolio
Ninetails, a neural network that uses Nanopore Direct RNA sequencing data to identify non-A residues in mRNA poly(A) tails is presented. Particularly non-A of therapeutic, mitochondrial ...