The resulting copper difluorocarbenoid complex coordinates with the epoxide and triggers site-selective ring cleavage and cyclization, to yield the desired α,α-difluoro-oxetane product via a ...

The resulting copper difluorocarbenoid complex coordinates with the epoxide and triggers site-selective ring cleavage and cyclisation, to yield the desired α,α-difluoro-oxetane product via a ...

Small, polar rings and electron-withdrawing atoms are both well-loved motifs in medicinal chemistry. So oxetanes and fluorine atoms could be a match made in drug discovery heaven. Researchers also ...

This copper-difluorocarbenoid intermediate interacts precisely with epoxides, initiating a ring-opening process followed by cyclization to form the desired α,α-difluoro-oxetanes. Professor Liu ...

Chem. 2025, DOI: 10.1038/s41557-024-01730-7). It wasn’t easy, Koh says: epoxides are prone to ring-opening reactions, and fluorinated carbenes also tend to bust rings open. The team carried out ...

The resulting copper difluorocarbenoid complex coordinates with the epoxide and triggers site-selective ring cleavage and cyclisation, to yield the desired α,α-difluoro-oxetane product via a ...

You'll need one of the best ring lights if you're looking to improve the look and feel of your online content or video calls. If you're a vlogger or influencer, particularly a fashion or beauty ...

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