The Cardinals are 4.5-point favorites in the matchup. The Cardinals will have their healthy starters playing. The 49ers will not have starting quarterback Brock Purdy, who has an elbow injury. Instead ...

The Arizona Cardinals' final game of the season is Sunday at State Farm Stadium against the San Francisco 49ers. The ...

Who are the 10 greatest San Francisco 49ers of all time? FOX Sports Research compiled the list of Niner greats.

Steve Mariucci displayed a clock at 49ers headquarters reading “NOW ... NOW ... NOW” instead of the usual intervals of “1 ...

For years, the strength of the 49ers was their run defense. Now it stinks. Until recently, the 49ers had gone 55 games in a ...

There's no question that San Francisco 49ers legend Frank Gore, now serving as a football personnel advisor for the team, ...

Former San Francisco 49ers running back Frank Gore spoke to Matt Maiocco and Jennifer Lee Chan before Sunday's game against ...

There's no question that San Francisco 49ers legend Frank Gore, now serving as a football personnel advisor for the team, admires head coach Kyle Shanahan's offensive system. Speaking on NBC ...

49ers Place Aaron Banks on IR, Activate Tatum Bethune from IR; Other Roster Moves Ahead of #DETvsSF The San Francisco 49ers announced a series of roster moves ahead of their Week 17 matchup ...

It's been a disappointing season for both the San Francisco 49ers and Miami Dolphins. Each team came into the year with playoff expectations, but heading into Week 16, both teams have been all but ...

On top of that, Brock Purdy has not produced like he previously has. Kathy Laughlin, Sports Editor (Season record: 9-5): 49ers 27, Dolphins 24 It’s a matchup of 6-8 teams, and the Dolphins are ...

San Francisco 49ers' De'Vondre Campbell walks to the locker room in 2nd half of 12-6 loss to Los ... [+] Angeles Rams in NFL game at Levi's Stadium in Santa Clara, Calif., on Thursday, December 12 ...